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General chemoenzymatic route to two-stereocenter triketides employing assembly line ketoreductases

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Abstract

Modular polyketide synthases (PKSs) are enzymatic assembly lines that fuse carbon fragments into complex chiral products. Here, their synthetic logic is employed to chemoenzymatically generate two-stereocenter triketides. Each of the four stereoisomers was constructed in a stereocontrolled manner using C-acylation and two PKS ketoreductases possessing opposite stereoselectivities.

Graphical abstract: General chemoenzymatic route to two-stereocenter triketides employing assembly line ketoreductases

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Publication details

The article was received on 11 Oct 2019, accepted on 26 Nov 2019 and first published on 28 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC07966A
Chem. Commun., 2020, Advance Article

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    General chemoenzymatic route to two-stereocenter triketides employing assembly line ketoreductases

    Z. Zhang, A. J. Cepeda, M. L. Robles, M. Hirsch, K. Kumru, J. A. Zhou and A. T. Keatinge-Clay, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC07966A

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