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Bi(OAc)3/chiral phosphoric acid catalyzed enantioselective allylation of isatins

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Abstract

Herein, we disclosed an efficient protocol for the construction of chiral 3-allyl-3-hydroxyoxindoles via the enantioselective allylation reaction of isatins and allylboronates catalyzed by a simple binary acid Bi(OAc)3/CPA system under mild conditions. The synthetic utility of this strategy has been demonstrated through the formal synthesis of ent-CPC-1.

Graphical abstract: Bi(OAc)3/chiral phosphoric acid catalyzed enantioselective allylation of isatins

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Publication details

The article was received on 10 Oct 2019, accepted on 29 Nov 2019 and first published on 29 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC07944K
Chem. Commun., 2020, Advance Article

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    Bi(OAc)3/chiral phosphoric acid catalyzed enantioselective allylation of isatins

    J. Wang, Q. Zhang, Y. Li, X. Liu, X. Li and J. Cheng, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC07944K

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