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Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes

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Abstract

Organelle-specific delivery systems are of significant clinical interest. We demonstrate the use of common cyanine dyes Cy3 and Cy5 as vectors for targeting and delivering cargoes to mitochondria in cancer cells. Specifically, conjugation to the dyes can increase cytotoxicity by up to 1000-fold.

Graphical abstract: Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes

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Article information


Submitted
09 Oct 2019
Accepted
20 Feb 2020
First published
25 Mar 2020

This article is Open Access

Chem. Commun., 2020, Advance Article
Article type
Communication

Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes

A. R. Nödling, E. M. Mills, X. Li, D. Cardella, E. J. Sayers, S. Wu, A. T. Jones, L. Y. P. Luk and Y. Tsai, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC07931A

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