Asymmetric construction of quaternary α-nitro amides by palladium-catalyzed C(sp3)–H arylation

Abstract

Pd-Catalyzed enantioselective C(sp³)–H arylation of N-(o-Br-aryl) anilides has been disclosed, and quaternary α-nitro amides were constructed with up to 98% ee. The presence of the nitro group on the substrate enables the progress of the reaction and the ready transformation of the product to optically active quaternary amino acid derivatives.