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Issue 15, 2020
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Asymmetric construction of quaternary α-nitro amides by palladium-catalyzed C(sp3)–H arylation

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Abstract

Pd-Catalyzed enantioselective C(sp3)–H arylation of N-(o-Br-aryl) anilides has been disclosed, and quaternary α-nitro amides were constructed with up to 98% ee. The presence of the nitro group on the substrate enables the progress of the reaction and the ready transformation of the product to optically active quaternary amino acid derivatives.

Graphical abstract: Asymmetric construction of quaternary α-nitro amides by palladium-catalyzed C(sp3)–H arylation

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Article information


Submitted
07 Oct 2019
Accepted
20 Jan 2020
First published
20 Jan 2020

Chem. Commun., 2020,56, 2292-2295
Article type
Communication

Asymmetric construction of quaternary α-nitro amides by palladium-catalyzed C(sp3)–H arylation

W. Kong, S. Xie, C. Cao, C. Zhang, C. Wang and W. Duan, Chem. Commun., 2020, 56, 2292
DOI: 10.1039/C9CC07854A

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