Novel biotinylated diazido-Pt(IV) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all-trans-[Pt(py)2(N3)2(biotin)(OH)] (2a) were enhanced significantly when bound to avidin; irradiation induced dramatic cellular morphological changes in human ovarian cancer cells treated with 2a.
H. Shi, C. Imberti, H. Huang, I. Hands-Portman and P. J. Sadler, Chem. Commun., 2020, 56, 2320 DOI: 10.1039/C9CC07845B
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