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De novo design of thioredoxin reductase-targeted heterometallic titanocene–gold compounds of chlorambucil for mechanistic insights into renal cancer

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Abstract

Here we report the design and synthesis of a chlorambucil-alkynyl (CHL-CCH) ligand, mononuclear gold(I) complex K[(CHL-CC)AuCl], 1, and heteronuclear complex (CHL-CC)Au(μ22-CS3)Ti(η5-Cp)2, 2 for renal cancer. Complex 2 is significantly more cytotoxic than complex 1 and cisplatin against renal cancer cells with a high selectivity index value. The mechanism of action of these complexes against renal cancer cells was studied in detail by experimental and computational methods.

Graphical abstract: De novo design of thioredoxin reductase-targeted heterometallic titanocene–gold compounds of chlorambucil for mechanistic insights into renal cancer

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Publication details

The article was received on 20 Sep 2019, accepted on 29 Nov 2019 and first published on 30 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC07406F
Chem. Commun., 2020, Advance Article

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    De novo design of thioredoxin reductase-targeted heterometallic titanocene–gold compounds of chlorambucil for mechanistic insights into renal cancer

    L. Tabrizi, L. O. Olasunkanmi and O. A. Fadare, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC07406F

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