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Development of a deep-red fluorescent glucose-conjugated bioprobe for in vivo tumor targeting

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Abstract

A C1-type D-glucose-conjugated fluorescent probe Glu-1-O-DCSN was synthesized and showed deep-red emission at 685 nm with a Stokes shift of up to 150 nm in DMSO. In in vitro live cell imaging, Glu-1-O-DCSN exhibited similar and competitive uptake behaviours to D-glucose and was selectively located in mitochondria. Furthermore, Glu-1-O-DCSN was successfully employed for in vivo hypermetabolic tumor targeting.

Graphical abstract: Development of a deep-red fluorescent glucose-conjugated bioprobe for in vivo tumor targeting

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Article information


Submitted
24 Sep 2019
Accepted
07 Dec 2019
First published
13 Dec 2019

Chem. Commun., 2020, Advance Article
Article type
Communication

Development of a deep-red fluorescent glucose-conjugated bioprobe for in vivo tumor targeting

Y. Cheng, G. Shabir, X. Li, L. Fang, L. Xu, H. Zhang and E. Li, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC07363A

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