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An automated modular assembly line for drugs in a miniaturized plant

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Abstract

We report here a fully automated, end-to-end, integrated continuous manufacturing process for a small-molecule generic medication with built-in quality assurance. The entire process fits into a box of 30.7 m2 modular footprint and a total residence time of less than 30 h, with a throughput up to 40.3 × 106 tablets per year.

Graphical abstract: An automated modular assembly line for drugs in a miniaturized plant

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Article information


Submitted
10 Sep 2019
Accepted
09 Dec 2019
First published
09 Dec 2019

Chem. Commun., 2020, Advance Article
Article type
Communication

An automated modular assembly line for drugs in a miniaturized plant

C. Hu, C. J. Testa, W. Wu, K. Shvedova, D. E. Shen, R. Sayin, B. S. Halkude, F. Casati, P. Hermant, A. Ramnath, S. C. Born, B. Takizawa, T. F. O’Connor, X. Yang, S. Ramanujam and S. Mascia, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC06945C

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