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Issue 1, 2020
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Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis

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Abstract

Using a covalent chemical probe and X-ray crystallography coupled to nuclear magnetic resonance data, we elucidated the dynamic molecular basis of protein recognition between the carrier protein and adenylation domain in pyoluteorin biosynthesis. These findings reveal a unique binding mode, which contrasts previously solved carrier protein and partner protein interfaces.

Graphical abstract: Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis

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Article information


Submitted
27 Dec 2019
Accepted
26 Feb 2020
First published
24 Mar 2020

This article is Open Access

RSC Chem. Biol., 2020,1, 8-12
Article type
Communication

Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis

J. C. Corpuz, L. M. Podust, T. D. Davis, M. J. Jaremko and M. D. Burkart, RSC Chem. Biol., 2020, 1, 8
DOI: 10.1039/C9CB00015A

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