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Antibacterial nanosystems for cancer therapy

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Abstract

Bacteria and cancer cells share a unique symbiotic relationship in the process of cancer development and treatment. It has been shown that certain bacteria can mediate cancer and thrive inside cancerous tissues. Moreover, during cancer treatment, microbial infections have been shown to impair the therapeutic efficacy and lead to serious complications. In the past decades, the application of antibiotics has achieved great success in fighting numerous bacteria but the administration route, low localization effects and related drug resistance limit the further utilization of antibiotics. Recently, advances in nanotechnology have made a significant impact in the medical field, which enhance the drug solubility and can target lesion sites, and some nanomaterials can even be applied as the therapeutic agent itself. In this review, we introduce anti-bacterial nanosystems for cancer therapy in the aspects of spontaneous and triggered anti-bacterial action, and our notions, as well as proposed research directions for the further development of this field, are discussed.

Graphical abstract: Antibacterial nanosystems for cancer therapy

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Article information


Submitted
10 Sep 2020
Accepted
06 Oct 2020
First published
06 Oct 2020

Biomater. Sci., 2020, Advance Article
Article type
Review Article

Antibacterial nanosystems for cancer therapy

J. Rao, Y. Yang, H. Pan Bei, C. Tang and X. Zhao, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/D0BM01537G

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