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Single-Atom Nanozymes for Biological Application


Nanozymes have been widely used as highly active and stable arterial enzyme due to controllable electronic transfer and the unique catalytic reaction route. However, the development of nanozymes are hindered by its ambiguous structure, insufficient activity and inadequate substrate selectivity. In comparison, single-atom nanozymes (SAzymes) hold superior catalytic activity 10-100 times higher than conventional nanozymes by maximizing the utilization of metal atom dispersion, and exhibit versatile catalytic selectivity through precisely adjusting atom spatial configuration. In this review, we highlight several well-defined SAzymes, and discuss their accurate atom configuration, catalytic mechanisms, enzyme-like activity, and the applications in cancer treatment, brain disease, and wound healing. It is of great significance to understand the advantages and properties of SAzymes for further medical development.

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Article information

27 Aug 2020
29 Sep 2020
First published
01 Oct 2020

Biomater. Sci., 2020, Accepted Manuscript
Article type
Review Article

Single-Atom Nanozymes for Biological Application

J. Pei, R. Zhao, X. Mu, J. Wang, C. Liu and X. Zhang, Biomater. Sci., 2020, Accepted Manuscript , DOI: 10.1039/D0BM01447H

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