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Peptide-based aggregation-induced emission bioprobe for selective detection and photodynamic killing of Gram-negative bacteria

Abstract

Herein, we report a new bioprobe with aggregation-induced emission (AIE) characteristics by conjugation of a far-red/near-infrared emissive AIE lumogen and two polymyxinB peptides. Due to the strong binding effect between polymyxinB and lipopolysaccharide in the cell wall of Gram-negative bacteria, the bioprobe can selectively visualize Gram-negative bacteria and effectively kill them via photodynamic treatment.

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Supplementary files

Article information


Submitted
10 Aug 2020
Accepted
14 Oct 2020
First published
17 Oct 2020

Biomater. Sci., 2020, Accepted Manuscript
Article type
Communication

Peptide-based aggregation-induced emission bioprobe for selective detection and photodynamic killing of Gram-negative bacteria

P. Bao, C. Li, H. Ou, S. Ji, Y. Chen, J. Gao, X. Yue, J. Shen and D. Ding, Biomater. Sci., 2020, Accepted Manuscript , DOI: 10.1039/D0BM01330G

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