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Green facile synthesis to develop nanoscale coordination polymers as lysosome-targetable luminescent bioprobes

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Abstract

Three new coordination polymers (CPs), namely [{M(HL)(L)(H2O)}(ClO4)(H2O)] (M = Zn for CP 1, Mn for CP 2, Cu for CP 3) were synthesized to explore their efficacy as lysosome-targetable luminescent bioprobes. The synthesized CPs were characterized by techniques including single-crystal X-ray analysis, FTIR spectroscopy and elemental analysis. Single-crystal analysis revealed the formation of iso-structural CPs displaying distorted adamantoid topology developed by bridging ligands and H-bonds connections and metals at the nodes. A green hand-grinding technique with a mortar and pestle resulted in nanoscale coordination polymers (NCPs) suitable for cell permeability and was further confirmed by SEM and DLS analyses. Two of these hand-ground nanoscale coordination polymers NCP 1 and NCP 2 showed excellent green luminescence and were explored as potential and selective long-time biotrackers towards lysosome using the human lung carcinoma cell line (A549). Strikingly, the developed bioprobe displayed excellent bio-availability, photostability and excellent selectivity towards lysosomes sustained by various in vitro cell imaging experiments. Moreover, the long-term probing ability of these NCPs turned out to be better than the commercially available lysosome tracker i.e. LysoTracker Red, indicating their potential real-life application in bio-imaging. To the best ofour knowledge, this is the first example of nonexpensive and less toxic essential transition metal-based nanoscale coordination polymers that can behave as effective lysosome-targetable luminescent bioprobes.

Graphical abstract: Green facile synthesis to develop nanoscale coordination polymers as lysosome-targetable luminescent bioprobes

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Article information


Submitted
09 Aug 2020
Accepted
26 Sep 2020
First published
29 Sep 2020

Biomater. Sci., 2020, Advance Article
Article type
Paper

Green facile synthesis to develop nanoscale coordination polymers as lysosome-targetable luminescent bioprobes

S. Karim, S. Mukherjee, S. Mahapatra, R. Parveen and D. Das, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/D0BM01328E

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