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Green facile synthesis to develop nanoscale coordination polymers as lysosome targetable luminescent bioprobe


Three new coordination polymers (CPs), namely [{M(HL)(L)(H2O)}(ClO4)(H2O)]∞ (M = Zn for CP 1, Mn for CP 2, Cu for CP 3) have been synthesized to explore their efficacy as lysosome targetable luminescent bioprobe. Synthesized CPs have been characterized by single-crystal X-Ray analysis, FTIR spectroscopy, elemental analysis, etc. Single crystal analysis revealed the formation of iso-structural CPs displaying distorted Adamantoid topology developed by bridging ligands and H-bonds connections and metals at nodes. A green hand grinding technique with mortar and pestle resulted in nanoscale coordination polymers (NCPs) suitable for cell permeability and further confirmed by SEM and DLS analysis. Two of such hand-ground nanoscale coordination polymers NCP 1 and NCP 2 showed excellent green luminescence and were explored as potential and selective long-time bio tracker towards lysosome using human lung carcinoma cell line (A549). Strikingly, the developed bio-probe displayed excellent bio-availability, photostability, and excellent selectivity towards lysosomes sustained by various in-vitro cell imaging experiments. Moreover, the long-term probing ability of these NCPs turned to be better compared to the commercially available lysosome tracker i.e. LysoTracker Red, indicating their potential real-life application in bio-imaging. To our knowledge this is the first example of nonexpensive and less toxic essential transitional metal-based nanoscale coordination polymers behave as effective lysosome targetable luminescent bioprobe.

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Supplementary files

Article information

09 Aug 2020
26 Sep 2020
First published
29 Sep 2020

Biomater. Sci., 2020, Accepted Manuscript
Article type

Green facile synthesis to develop nanoscale coordination polymers as lysosome targetable luminescent bioprobe

S. Karim, S. Mukherjee, S. Mahapatra, R. Parveen and D. Das, Biomater. Sci., 2020, Accepted Manuscript , DOI: 10.1039/D0BM01328E

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