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Eco-friendly development of an ultrasmall IONP-loaded nanoplatform for bimodal imaging-guided cancer theranostics

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Abstract

Success in disease therapy depends on precision medicines, where development of formulations with diagnostic and therapeutic functions is quite important. In this study, multifunctional theranostics based on a magnetic graphene oxide (GO) nanohybrid (GIPD) has been developed for magnetic resonance (MR) imaging-guided chemo-photothermal therapy of cancer. The GIPD is endowed with T1/T2 MR imaging capacity via precipitation of small-sized IONP nanoparticles (8.25 ± 2.25 nm) on GO nanosheets through a mild friendly way (60 °C for 1 h, no organic solvent). The obtained nanocomposite is then non-covalently decorated with phosphine oxide polyethylene glycol to improve biosafety. The final nanohybrid effectively loads doxorubicin as the model chemotherapeutic drug and is found to have in vivo T1/T2 MR bimodal imaging functions. Both the in vitro and in vivo results demonstrate that the GO-based nanoplatform displays a good remote photothermal effect, which can damage the dense shell of solid tumor tissue, thereby facilitating the delivery of anticancer drugs into tumor cells. Therefore, this theranostic nanoplatform enables a potent combined chemo-photothermal anticancer efficacy, holding great potential for exploitation of precision cancer therapy.

Graphical abstract: Eco-friendly development of an ultrasmall IONP-loaded nanoplatform for bimodal imaging-guided cancer theranostics

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Supplementary files

Article information


Submitted
25 May 2020
Accepted
31 Aug 2020
First published
11 Sep 2020

Biomater. Sci., 2020, Advance Article
Article type
Paper

Eco-friendly development of an ultrasmall IONP-loaded nanoplatform for bimodal imaging-guided cancer theranostics

Y. Li, L. Zheng, L. Xiao, L. Wang, J. Cui, D. Sha and C. Liu, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/D0BM00867B

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