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Viscoelasticity of hydrazone crosslinked poly(ethylene glycol) hydrogels directs chondrocyte morphology during mechanical deformation

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Abstract

Chondrocyte deformation influences disease progression and tissue regeneration in load-bearing joints. In this work, we found that viscoelasticity of dynamic covalent crosslinks temporally modulates the biophysical transmission of physiologically relevant compressive strains to encapsulated chondrocytes. Chondrocytes in viscoelastic alky-hydrazone hydrogels demonstrated (91.4 ± 4.5%) recovery of native rounded morphologies during mechanical deformation, whereas primarily elastic benzyl-hydrazone hydrogels significantly limited morphological recovery (21.2 ± 1.4%).

Graphical abstract: Viscoelasticity of hydrazone crosslinked poly(ethylene glycol) hydrogels directs chondrocyte morphology during mechanical deformation

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Article information


Submitted
22 May 2020
Accepted
19 Jun 2020
First published
23 Jun 2020

Biomater. Sci., 2020, Advance Article
Article type
Communication

Viscoelasticity of hydrazone crosslinked poly(ethylene glycol) hydrogels directs chondrocyte morphology during mechanical deformation

B. M. Richardson, C. J. Walker, L. J. Macdougall, J. W. Hoye, M. A. Randolph, S. J. Bryant and K. S. Anseth, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/D0BM00860E

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