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Affinity of plant viral nanoparticle potato virus X (PVX) towards malignant B cells enables cancer drug delivery

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Abstract

Non-Hodgkin's B cell lymphomas (NHL) include a diverse set of neoplasms that constitute ∼90% of all lymphomas and the largest subset of blood cancers. While chemotherapy is the first line of treatment, the efficacy of contemporary chemotherapies is hampered by dose-limiting toxicities. Partly due to suboptimal dosing, ∼40% of patients exhibit relapsed or refractory disease. Therefore more efficacious drug delivery systems are urgently needed to improve survival of NHL patients. In this study we demonstrate a new drug delivery platform for NHL based on the plant virus Potato virus X (PVX). We observed a binding affinity of PVX towards malignant B cells. In a metastatic mouse model of NHL, we show that systemically administered PVX home to tissues harboring malignant B cells. When loaded with the chemotherapy monomethyl auristatin (MMAE), the PVX nanocarrier enables effective delivery of MMAE to human B lymphoma cells in a NHL mouse model leading to inhibition of lymphoma growth in vivo and improved survival. Thus, PVX nanoparticle is a promising drug delivery platform for B cell malignancies.

Graphical abstract: Affinity of plant viral nanoparticle potato virus X (PVX) towards malignant B cells enables cancer drug delivery

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Supplementary files

Article information


Submitted
29 Apr 2020
Accepted
10 Jun 2020
First published
17 Jun 2020

Biomater. Sci., 2020, Advance Article
Article type
Paper

Affinity of plant viral nanoparticle potato virus X (PVX) towards malignant B cells enables cancer drug delivery

S. Shukla, A. J. Roe, R. Liu, F. A. Veliz, U. Commandeur, D. N. Wald and N. F. Steinmetz, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/D0BM00683A

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