Smart theranostic agent based on Fe-HPPy@Au/DOX for CT imaging and PTT/chemotherapy/CDT combined anticancer therapy
We herein explored a smart Fe-HPPy@Au/DOX theranostic agent to achieve CT diagnosis and PTT/chemotherapy/CDT synergistic treatment of cancer. When the Fe-HPPy@Au/DOX theranostic agent entered the tumor, the trapped Fe ion accelerated release to catalyze the production of •OH for CDT. NIR irradiation drove the PTT, at the same time improved the CDT by enhancing the •OH producing amounts and triggered the DOX release for chemotherapy. In addition, the Au nanoparticles on the surface of Fe-HPPy@Au nanocomposites could be used as CT imaging agent and catalyzer to produce H2O2 for enhanced CDT.