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The mannose 6-phosphate receptor targeted with porphyrin-based periodic mesoporous organosilica nanoparticles for rhabdomyosarcoma theranostics

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Abstract

Porphyrin-based periodic mesoporous organosilica nanoparticles (PMO) synthesized from a large functional octatriethoxysilylated porphyrin precursor and allowing two-photon excitation photodynamic therapy (TPE-PDT) and NIR imaging were synthesized. These PMO were grafted with polyethylene glycol (PEG) moieties and an analogue of mannose 6-phosphate functionalized at the anomeric position (AMFA). AMFAs are known to efficiently target mannose 6-phosphate receptors (M6PRs) which are over-expressed in various cancers. Here, we demonstrated for the first time that M6PRs were over-expressed in rhabdomyosarcoma (RMS) cells and could be efficiently targeted with PMO–AMFA allowing TPE imaging and TPE-PDT of RMS cells. The comparison with healthy myoblasts demonstrated an absence of biological effects, suggesting a cancer cell specificity in the biomedical action observed.

Graphical abstract: The mannose 6-phosphate receptor targeted with porphyrin-based periodic mesoporous organosilica nanoparticles for rhabdomyosarcoma theranostics

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Article information


Submitted
13 Apr 2020
Accepted
17 May 2020
First published
18 May 2020

Biomater. Sci., 2020, Advance Article
Article type
Paper

The mannose 6-phosphate receptor targeted with porphyrin-based periodic mesoporous organosilica nanoparticles for rhabdomyosarcoma theranostics

M. Daurat, C. Nguyen, S. Dominguez Gil, V. Sol, V. Chaleix, C. Charnay, L. Raehm, K. El Cheikh, A. Morère, M. Bernasconi, A. Timpanaro, M. Garcia, F. Cunin, J. Roessler, J. Durand and M. Gary-Bobo, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/D0BM00586J

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