Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Hollow ferric-tannic acid nanocapsules with sustained O2 and ROS induction for synergistic tumor therapy

Author affiliations

Abstract

Nanoparticles presenting promoted catalytic activity, oxygen induction and loading capability are in high demand for effective synergistic tumor therapy. Herein, ferric-tannic acid complex nanocapsules with fine hollow microstructure (HFe-TA) are synthesized and loaded with a photosensitizer (indocyanine green, ICG) for synergistic tumor therapy. In acidic environment, ICG@HFe-TA decomposes and releases Fe3+ ions, TA and ICG molecules. Fe3+, with low catalytic activity, is effectively converted into highly catalytic Fe2+ by the reductant TA, enabling promoted efficacy of ˙OH induction. More importantly, the ROS (1O2) induction by ICG is significantly enhanced under 808 nm laser irradiation due to the O2 byproduct of Fe3+/Fe2+ conversion. In consequence, the ICG@HFe-TA nanoparticles exhibit considerable in vitro and in vivo tumor inhibition owing to the combined effect of ˙OH and 1O2 induced intracellularly. This study has therefore demonstrated a potential platform enabling combined photodynamic and chemodynamic therapy with high efficacy.

Graphical abstract: Hollow ferric-tannic acid nanocapsules with sustained O2 and ROS induction for synergistic tumor therapy

Back to tab navigation

Supplementary files

Article information


Submitted
03 Apr 2020
Accepted
06 Jun 2020
First published
10 Jun 2020

Biomater. Sci., 2020, Advance Article
Article type
Paper

Hollow ferric-tannic acid nanocapsules with sustained O2 and ROS induction for synergistic tumor therapy

H. Zhu, G. Cao, C. Qiang, Y. Fu, Y. Wu, X. Li and G. Han, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/D0BM00533A

Social activity

Search articles by author

Spotlight

Advertisements