Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Mild-heat-inducible sequentially released liposomal complex remodels the tumor microenvironment and reinforces anti-breast-cancer therapy

Author affiliations

Abstract

Increasing evidence indicates that the tumor microenvironment (TME) imposes various obstacles in response to chemotherapies. Sodium tanshinone IIA sulfonate (STS) has a validated ability to repair the unfavorable TME, providing a suitable environment for celastrol-based chemotherapy. However, remodeling TME still possesses enormous challenges for STS due to the difficulty in a controlled release at tumor sites. Gold nanorods (GNRs) capable of converting near-infrared (NIR) light into heat offer a promising trigger approach to regulate the local drug release. Here, we fabricated a gold nanorod-anchored thermosensitive liposomal complex co-loaded with STS and celastrol (G–T/C–L), which could sequentially release STS and celastrol upon NIR irradiation at 808 nm. When G–T/C–L reaches the sites, NIR illumination produces mild heat (∼43 °C) and thereby triggers a rapid release of STS in the initial stage, decreasing the level of tumoral blood vessels, collagen, cancer-associated fibroblasts, and Th2 type cytokines. In the subsequent stage, celastrol was unloaded to exert an anticancer effect under an activated TME. In proof-of-concept studies, the treatment of G–T/C–L with NIR illumination showed a significant improvement in anticancer efficacy both in vitro and in vivo but without conventional photothermal therapy-associated side effects. This study proposes photothermal-triggered technology to realize controlled drug release, enriching the application with combinational STS and celastrol in anti-breast cancer therapy.

Graphical abstract: Mild-heat-inducible sequentially released liposomal complex remodels the tumor microenvironment and reinforces anti-breast-cancer therapy

Back to tab navigation

Supplementary files

Article information


Submitted
26 Mar 2020
Accepted
02 Jun 2020
First published
03 Jun 2020

Biomater. Sci., 2020, Advance Article
Article type
Paper

Mild-heat-inducible sequentially released liposomal complex remodels the tumor microenvironment and reinforces anti-breast-cancer therapy

Y. Qin, T. Liu, M. Guo, Y. Liu, C. Liu, Y. Chen and D. Qu, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/D0BM00498G

Social activity

Search articles by author

Spotlight

Advertisements