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A lysozyme corona complex for the controlled pharmacokinetic release of probucol from mesoporous silica particles

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Abstract

Mesoporous silica particles (MSPs) enhance the release kinetics of poorly soluble compound probucol (PB) under the influence of a pore-blocking protein corona, prepared with lysozyme protein adsorption. In vivo oral administration experiments show a prolongation in the time to reach maximum systemic concentration and half-life of PB released from the lysozyme-MSP complex in comparison to the MSP alone. Specific hard protein corona complexes can act as functional diffusion barriers for the controlled release of drugs from MSP based formulations.

Graphical abstract: A lysozyme corona complex for the controlled pharmacokinetic release of probucol from mesoporous silica particles

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Article information


Submitted
18 Mar 2020
Accepted
13 Jun 2020
First published
15 Jun 2020

Biomater. Sci., 2020, Advance Article
Article type
Communication

A lysozyme corona complex for the controlled pharmacokinetic release of probucol from mesoporous silica particles

K. Giri, M. Lau, I. Kuschnerus, I. Moroni and A. E. Garcia-Bennett, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/D0BM00445F

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