Development of new self-assembled cationic amino liposomes for efficient gene delivery

Yihang Wu; Yue Xiong; Ling Wang; Quanming Zhou; Linxian Li; Pavel A. Levkin; Gary Davidson; Liqian Gao; Wenbin Deng

doi:10.1039/D0BM00331J

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Development of new self-assembled cationic amino liposomes for efficient gene delivery†

Yihang Wu,‡^ab Yue Xiong,‡^a Ling Wang,‡^a Quanming Zhou,^a Linxian Li,^b Pavel A. Levkin,

^b Gary Davidson,*^b Liqian Gao

*^a and Wenbin Deng*^a

Author affiliations

* Corresponding authors

^a School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, P.R. China
E-mail: gaolq@mail.sysu.edu.cn, glqustc@gmail.com, dengwb5@mail.sysu.edu.cn

^b Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, 76344 Karlsruhe, Germany
E-mail: gary.davidson@kit.edu

Abstract

A library of 83 structurally diverse cationic amino liposomes is rationally designed and parallelly synthesized for the transfection of plasmid DNA and siRNA. Our designed self-assembled liposomes not only exhibit excellent transfection efficiency in HEK 293T cells and mouse embryonic stem cells, but also show low cytotoxicity.

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Article information

DOI: https://doi.org/10.1039/D0BM00331J
Article type: Communication
Submitted: 29 Feb 2020
Accepted: 06 Apr 2020
First published: 06 Apr 2020

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Biomater. Sci., 2020,8, 3021-3025

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Development of new self-assembled cationic amino liposomes for efficient gene delivery

Y. Wu, Y. Xiong, L. Wang, Q. Zhou, L. Li, P. A. Levkin, G. Davidson, L. Gao and W. Deng, Biomater. Sci., 2020, 8, 3021 DOI: 10.1039/D0BM00331J

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Biomaterials Science

Development of new self-assembled cationic amino liposomes for efficient gene delivery†

Abstract

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Development of new self-assembled cationic amino liposomes for efficient gene delivery

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