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Development of new self-assembled cationic amino liposomes for efficient gene delivery

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Abstract

A library of 83 structurally diverse cationic amino liposomes is rationally designed and parallelly synthesized for the transfection of plasmid DNA and siRNA. Our designed self-assembled liposomes not only exhibit excellent transfection efficiency in HEK 293T cells and mouse embryonic stem cells, but also show low cytotoxicity.

Graphical abstract: Development of new self-assembled cationic amino liposomes for efficient gene delivery

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Article information


Submitted
29 Feb 2020
Accepted
06 Apr 2020
First published
06 Apr 2020

Biomater. Sci., 2020, Advance Article
Article type
Communication

Development of new self-assembled cationic amino liposomes for efficient gene delivery

Y. Wu, Y. Xiong, L. Wang, Q. Zhou, L. Li, P. A. Levkin, G. Davidson, L. Gao and W. Deng, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/D0BM00331J

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