Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



A super-stretchable, self-healing and injectable supramolecular hydrogel constructed by a host–guest crosslinker

Author affiliations

Abstract

Supramolecular hydrogels based on host–guest interactions have drawn considerable attention due to their unique properties and promising applications. However, it is still a great challenge to construct supramolecular hydrogels that simultaneously achieve mechanical strength, processability, and biocompatibility. Herein, we present a rational design of a “supramolecular crosslinker” approach to fabricate a new host–guest hydrogel with super-stretchability, self-healing, and injectable properties and excellent biocompatibility. The star-shaped supramolecular crosslinker is formed by the host–guest interactions between octa-cyclodextrin polyhedral oligomeric silsesquioxane (OCDPOSS) and acrylamide-modified adamantane (Ad-AAm). Supramolecular hydrogels can be briefly prepared by UV-initiated copolymerization of acrylamide and supramolecular crosslinkers. Supramolecular hydrogels present impressive mechanical properties due to rigid POSS as the core of the supramolecular crosslinker. Moreover, multivalent host–guest interactions improve the ductility, rapid self-healing and injectable ability of these hydrogels. Simultaneously, these supramolecular hydrogels possess good biocompatibility and can be utilized as carriers for the sustained release of hydrophobic drugs. Thus, such supramolecular hydrogels will have potential applications for tissue engineering and drug delivery systems.

Graphical abstract: A super-stretchable, self-healing and injectable supramolecular hydrogel constructed by a host–guest crosslinker

Back to tab navigation

Supplementary files

Article information


Submitted
21 Feb 2020
Accepted
22 Apr 2020
First published
23 Apr 2020

Biomater. Sci., 2020, Advance Article
Article type
Paper

A super-stretchable, self-healing and injectable supramolecular hydrogel constructed by a host–guest crosslinker

Y. Zhou, Y. Zhang, Z. Dai, F. Jiang, J. Tian and W. Zhang, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/D0BM00290A

Social activity

Search articles by author

Spotlight

Advertisements