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Overview of the application of inorganic nanomaterials in cancer photothermal therapy

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Abstract

Cancer photothermal therapy (PTT) has captured the attention of researchers worldwide due to its localized and trigger-activated therapeutic effect. In this field, nanomaterials capable of converting the energy of the irradiation light into heat have been showing promising results in several pre-clinical and clinical assays. Such a therapeutic modality takes advantage of the innate capacity of nanomaterials to accumulate in the tumor tissue and their capacity to interact with NIR laser irradiation to exert a therapeutic effect. Therefore, several nanostructures composed of different materials and organizations for mediating a photothermal effect have been developed. In this review, the most common inorganic nanomaterials, such as gold, carbon-based materials, tungsten, copper, molybdenum, and iron oxide, which have been explored for mediating a tumor-localized photothermal effect, are summarized. Moreover, the physicochemical parameters of nanoparticles that influence the PTT effectiveness are discussed and the recent clinical advances involving inorganic nanomaterial-mediated cancer photothermal therapy are also presented.

Graphical abstract: Overview of the application of inorganic nanomaterials in cancer photothermal therapy

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Article information


Submitted
10 Feb 2020
Accepted
14 Apr 2020
First published
15 Apr 2020

Biomater. Sci., 2020, Advance Article
Article type
Review Article

Overview of the application of inorganic nanomaterials in cancer photothermal therapy

N. Fernandes, C. F. Rodrigues, A. F. Moreira and I. J. Correia, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/D0BM00222D

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