Jump to main content
Jump to site search


Injectable hydrogel systems with multiple biophysical and biochemical cues for bone regeneration

Author affiliations

Abstract

Bone regeneration is a complex process in which angiogenesis and osteogenesis are crucial. Introducing multiple angiogenic and osteogenic cues simultaneously into a single system and tuning these cues to optimize the niche remains a challenge for bone tissue engineering. Herein, based on our injectable biomimetic hydrogels composed of silk nanofibers (SNF) and hydroxyapatite nanoparticles (HA), deferoxamine (DFO) and bone morphogenetic protein-2 (BMP-2) were loaded on SNF and HA to introduce more angiogenic and osteogenic cues. The angiogenesis and osteogenesis capacity of injectable hydrogels could be regulated by tuning the delivery of DFO and BMP-2 independently, resulting in vascularization and bone regeneration in cranial defects. The angiogenesis and osteogenesis outcomes accelerated the regeneration of vascularized bones toward similar composition and structure to natural bones. Therefore, the multiple biophysical and chemical cues provided by the nanofibrous structures, organic–inorganic compositions, and chemical and biochemical angiogenic and osteogenic inducing cues suggest the potential for clinical applicability of these hydrogels in bone tissue engineering.

Graphical abstract: Injectable hydrogel systems with multiple biophysical and biochemical cues for bone regeneration

Back to tab navigation

Supplementary files

Article information


Submitted
19 Jan 2020
Accepted
18 Mar 2020
First published
19 Mar 2020

Biomater. Sci., 2020, Advance Article
Article type
Paper

Injectable hydrogel systems with multiple biophysical and biochemical cues for bone regeneration

W. Cheng, Z. Ding, X. Zheng, Q. Lu, X. Kong, X. Zhou, G. Lu and D. L. Kaplan, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/D0BM00104J

Social activity

Search articles by author

Spotlight

Advertisements