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Bioinspired inorganic nanoparticles and vascular factor microenvironment directed neo-bone formation

Abstract

Various strategies have been explored to stimulate a new bone formation. Among these strategies, includes using angiogenic stimulants in combination with inorganic biomaterials. Neovascularization during the neo-bone formation provides nutrients along with bone-forming minerals. Therefore, it is crucial to design a bone stimulating microenvironment composed of both pro-angiogenic and osteogenic factors. In this respect, human vascular endothelial growth factors (hVEGF) have been shown to promote blood vessel formation and bone formation. Furthermore, in recent years, whitlockite (WH), a novel phase of magnesium-containing calcium phosphate derivatives that exist in our bone tissue, has been synthesized and applied in bone tissue engineering. In this study, our aim is to explore the potential use of hVEGF and WH for bone tissue engineering. Our study demonstrated that hVEGF and WH microenvironment synergistically stimulated osteogenic commitment of mesenchymal stem cells both in vitro and in vivo.

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Supplementary files

Article information


Submitted
08 Jan 2020
Accepted
14 Mar 2020
First published
17 Mar 2020

Biomater. Sci., 2020, Accepted Manuscript
Article type
Paper

Bioinspired inorganic nanoparticles and vascular factor microenvironment directed neo-bone formation

H. D. Kim, J. Park, S. A, R. Jayakumar and N. Hwang, Biomater. Sci., 2020, Accepted Manuscript , DOI: 10.1039/D0BM00041H

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