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Fabrication of strong hydrogen-bonding induced coacervate adhesive hydrogels with antibacterial and hemostatic activities

Abstract

In this work, a biocompatible poly(N-hydroxyethyl acrylamide) (PHEAA) with hydrogen bonding acceptors and donors in side chains is prepared and mixed with tannic acid (TA) to form a supramolecular coacervate hydrogel (TAHE) due to the multiple hydrogen-bonding interactions between TA and PHEAA. The coacervate TAHE hydrogel exhibits not only a self-healing and antibacterial property, but also strong adhesion to various substrates, with an average adhesion strength of 722 kPa, 522 kPa, 484 kPa, and 322 kPa to the substrate of iron, PMMA, ceramics, and glass, respectively. Notably, the hydrogel reformed from the rehydration of freeze-dried and ground TAHE hydrogel powder remains the initial adhesive performance and exhibits an excellent hemostatic ability. This novel adhesive hydrogel holds great potential as an adhesive hemostatic material for self-rescue in emergency situations.

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Supplementary files

Article information


Submitted
18 Dec 2019
Accepted
30 Dec 2019
First published
02 Jan 2020

Biomater. Sci., 2020, Accepted Manuscript
Article type
Paper

Fabrication of strong hydrogen-bonding induced coacervate adhesive hydrogels with antibacterial and hemostatic activities

D. Zhang, Z. Xu, H. Li, C. Fan, C. Cui, T. Wu, M. Xiao, Y. Yang, J. Yang and W. Liu, Biomater. Sci., 2020, Accepted Manuscript , DOI: 10.1039/C9BM02029B

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