Hyaluronic acid/Lysozyme self-assembled coacervate to promote cutaneous wound healing
Traditional hydrogel dressings are limited in practical applications due to the complexity of the preparation and low biocompatibility. So It has an urgent need to design wound dressing with simple preparation method, higher biocompatibility, and superior therapeutic effect. Additionally, using a polysaccharide/protein mixture system is an attractive method to prepare gel. In this study, simple mixture of hyaluronic acid/ lysozyme (HL) was used to obtain HL coacervate gel. HL coacervate has suitable viscoelasticity, excellent adhesion on skin tissue. We demonstrated its high-efficiency self-healing property to overcome fracture or deformation. HL coacervate showed a significant effect on promoting wound healing in full-thickness skin defect model. Compared to commercial 3M dressing, it has faster epithelial tissue regeneration and stronger collagen deposition. In addition, cytotoxicity and organ toxicity tests indicated high safety of it. In summary, HL coacervate has broad clinical application prospects as a wound dressing.