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Melanin-like nanoparticles loaded with an angiotensin antagonist for an improved photothermal cancer therapy

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Abstract

An abnormal tumor growth induces solid stress in tumors, thus reducing blood perfusion. As a result, the impaired blood perfusion, with dense interstitial matrix in tumors significantly reduces the penetration and efficacy of nanotherapeutics. In this study, we have developed a losartan-loaded polydopamine nanoparticle (PLST) for the enhanced delivery of nanoparticles to tumors and improved photothermal cancer therapy. Losartan, an angiotensin inhibitor, is also able to alleviate the solid stress in tumors. It was laden on polydopamine nanoparticles via π–π stacking and was released upon tumor extracellular acidity. PLST reduced collagen production in vitro along with the lowered expression of profibrotic factors of TGF-β1, CCN2, and TIMP-1. The in vivo studies reveal that PLST reduced solid stress in tumors, and the amount of PLST accumulated in tumors was enhanced. The efficiency of the photothermal ablation of tumors was significantly enhanced by using PLST.

Graphical abstract: Melanin-like nanoparticles loaded with an angiotensin antagonist for an improved photothermal cancer therapy

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Supplementary files

Article information


Submitted
15 Nov 2019
Accepted
31 Dec 2019
First published
08 Jan 2020

Biomater. Sci., 2020, Advance Article
Article type
Paper

Melanin-like nanoparticles loaded with an angiotensin antagonist for an improved photothermal cancer therapy

Z. Zhou, Y. Yan, Q. Zhang and Y. Cheng, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/C9BM01843C

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