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N-Oxide polymer–cupric ion nanogels potentiate disulfiram for cancer therapy

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Abstract

Disulfiram (DSF) exerts potent anticancer activity via the formation of chelates with copper or zinc ions in tumor tissues, but the low abundance of these ions in the tumor cannot sustain its antitumor activity. Herein, we show that a zwitterionic water-soluble N-oxide polymer, poly[2-(N-oxide-N,N-dimethylamino)ethyl methacrylate] (OPDMA), can complex cupric ions and form nanogels (OPDMA/Cu), which efficiently deliver copper ions to tumor tissue to potentiate DSF significantly for effective antitumor therapy.

Graphical abstract: N-Oxide polymer–cupric ion nanogels potentiate disulfiram for cancer therapy

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Article information


Submitted
13 Nov 2019
Accepted
13 Jan 2020
First published
14 Jan 2020

Biomater. Sci., 2020, Advance Article
Article type
Paper

N-Oxide polymer–cupric ion nanogels potentiate disulfiram for cancer therapy

Y. Zhong, R. Sun, Y. Geng, Q. Zhou, Y. Piao, T. Xie, R. Zhou and Y. Shen, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/C9BM01841G

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