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N-Oxide Polymer-Cupric Ion Nanogels Potentiate Disulfiram for Cancer Therapy

Abstract

Disulfiram (DSF) exerts potent anticancer activity via the formation of chelates with copper or zinc ions in tumor tissues, but the low abundance of these ions in the tumor cannot sustain its antitumor activity. Herein, we show that a zwitterionic water-soluble N-oxide polymer, poly[2-(N-oxide-N,N-dimethylamino)ethyl methacrylate] (OPDMA), can complex cupric ions and form nanogels (OPDMA/Cu2+), which efficiently deliver Cu2+ to tumor tissue to significantly potentiate DSF for effective antitumor therapy.

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Article information


Submitted
13 Nov 2019
Accepted
13 Jan 2020
First published
14 Jan 2020

Biomater. Sci., 2020, Accepted Manuscript
Article type
Paper

N-Oxide Polymer-Cupric Ion Nanogels Potentiate Disulfiram for Cancer Therapy

Y. Shen, Y. Zhong, R. Sun, Y. Geng, Q. Zhou, Y. Piao, T. Xie and R. Zhou, Biomater. Sci., 2020, Accepted Manuscript , DOI: 10.1039/C9BM01841G

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