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A Facile and Universal Strategy to Endow Implant Materials Antibacterial Ability via Alkalinity Disturbing Bacterial Respiration

Abstract

Multifarious strategies have been proposed to enhance the antibacterial ability of implants surfaces for preventing bacterial infection, however, developing facile and universal modification methods still remains extremely elusive. Herein, inspired by that the electron transfer respiratory chain of bacteria is embedded in the membrane, we proposed a novel strategy of local alkalinity disturbing bacterial respiration to endow implant materials with antibacterial ability. As a demonstration, MgO was deposited on biomedical titanium via magnetron sputtering to regulate surface alkalinity. With the thickness of MgO films increasing, it exhibited excellent antibacterial rate against both Gram-negative and positive bacteria. The antibacterial mechanism was confirmed that alkaline surface can disturb the bacterial respiration action via weakening the transmembrane proton concentration gradient, resulting in the block of energy metabolism and the increase of oxidative stress of bacteria. Cell experiments indicated that MgO films not only have no obvious cytotoxicity to osteoblast cells but also can selectively kill bacteria and promote cell proliferation in the presence of both bacteria and cells. More importantly, the by-product of MgO was only the biocompatible Mg2+, reducing any concerns about potential toxic effects. Furthermore, sputtering alkaline MgO film was confirmed to work well on polyetheretherketone polymer and zirconia ceramic implants, which indicates this strategy has broad prospects of clinic application for preventing implant-associated bacterial infection.

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Article information


Submitted
05 Nov 2019
Accepted
04 Jan 2020
First published
07 Jan 2020

Biomater. Sci., 2020, Accepted Manuscript
Article type
Paper

A Facile and Universal Strategy to Endow Implant Materials Antibacterial Ability via Alkalinity Disturbing Bacterial Respiration

J. Tan, Z. Liu, D. Wang, X. Zhang, S. Qian and X. Liu, Biomater. Sci., 2020, Accepted Manuscript , DOI: 10.1039/C9BM01793C

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