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A thin hydrogel barrier linked onto cell surface sialic acids through covalent bonds induces cancer cell death in vivo

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Abstract

Hypersialylation is the aberrant expression of sialic acid in cell surface glycans and is pervasive in cancer cells. Recent studies have shown that hypersialylation provides a microenvironment conducive to cancer progression, mediated by the interaction between sialic acid and sialic acid-binding receptors. Therefore, a technique to block the interaction between the overexpressed sialic acid on cancer cell surfaces and its receptors is a promising approach to develop new cancer therapies. We focused on hydrogels as an artificial barrier to block this interaction and present here the development of a novel technique for selectively covalently binding a thin hydrogel barrier on sialic acid residues on cancer cell surfaces. This technique effectively inhibited cancer cell adhesion, motility and growth, caused cancer cell death in vitro, and completely suppressed tumor growth in vivo, thereby clearly demonstrating a potent antitumor effect.

Graphical abstract: A thin hydrogel barrier linked onto cell surface sialic acids through covalent bonds induces cancer cell death in vivo

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Article information


Submitted
31 Oct 2019
Accepted
14 Dec 2019
First published
16 Dec 2019

Biomater. Sci., 2020, Advance Article
Article type
Communication

A thin hydrogel barrier linked onto cell surface sialic acids through covalent bonds induces cancer cell death in vivo

K. Ono, Y. Sanada, Y. Kimura, S. Aoyama, N. Ueda, T. Katayama and K. Nagahama, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/C9BM01758E

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