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Optimized fluorodendrimer-incorporated hybrid lipid–polymer nanoparticles for efficient siRNA delivery

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Abstract

Six cationic lipidoid fluorodendrimers are synthesized to construct hybrid lipid–polymer nanoparticles for siRNA delivery. By screening the nanoplatforms including fluorodendrimers with different chemical structures, the optimized nanoparticle NPF13-5 mediates the most efficient silencing of prohibitin 1, inhibition of cell proliferation, and induction of cell apoptosis towards A549 lung adenocarcinoma cells.

Graphical abstract: Optimized fluorodendrimer-incorporated hybrid lipid–polymer nanoparticles for efficient siRNA delivery

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Article information


Submitted
29 Oct 2019
Accepted
02 Jan 2020
First published
06 Jan 2020

Biomater. Sci., 2020, Advance Article
Article type
Communication

Optimized fluorodendrimer-incorporated hybrid lipid–polymer nanoparticles for efficient siRNA delivery

Q. Xiong, Y. Li, K. Zhou, P. Chen, H. Guo, L. Chen, J. Ding, T. Song and J. Shi, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/C9BM01738K

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