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Peptide polymer displaying potent activity against clinically isolated multidrug resistant Pseudomonas aeruginosa in vitro and in vivo

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Abstract

Multidrug resistant (MDR) Pseudomonas aeruginosa has caused serious nosocomial infections owing to its high intrinsic resistance and ease of acquiring resistance to common antibiotics. There is an urgent need to develop antimicrobial agents against MDR Pseudomonas aeruginosa. Here we report a 27-mer peptide polymer 90 : 10 DLL : BLG, as a synthetic mimic of a host defense peptide, that displayed potent in vitro and in vivo activities against multiple strains of clinically isolated MDR Pseudomonas aeruginosa, performing even better than antibiotics within our study. This peptide polymer also showed negligible hemolysis and low cytotoxicity, as well as quick bacterial killing efficacy. The structural diversity of peptide polymers, their easy synthesis from lithium hexamethyldisilazide-initiated fast N-carboxyanhydride polymerization, and the excellent reproducibility of their chemical structure and biological profiles altogether suggested great potential for antimicrobial applications of peptide polymers as synthetic mimics of host defense peptides.

Graphical abstract: Peptide polymer displaying potent activity against clinically isolated multidrug resistant Pseudomonas aeruginosa in vitro and in vivo

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Publication details

The article was received on 26 Oct 2019, accepted on 18 Nov 2019 and first published on 19 Nov 2019


Article type: Paper
DOI: 10.1039/C9BM01726G
Biomater. Sci., 2020, Advance Article

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    Peptide polymer displaying potent activity against clinically isolated multidrug resistant Pseudomonas aeruginosa in vitro and in vivo

    W. Jiang, X. Xiao, Y. Wu, W. Zhang, Z. Cong, J. Liu, S. Chen, H. Zhang, J. Xie, S. Deng, M. Chen, Y. Wang, X. Shao, Y. Dai, Y. Sun, J. Fei and R. Liu, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/C9BM01726G

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