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A multi-functional drug delivery system based on polyphenols for efficient tumor inhibition and metastasis prevention

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Abstract

Although chemotherapy is the most common method in clinical therapeutics with a straightforward mechanism, conventional anti-tumor drugs are still almost incapable of preventing the occurrence of tumor metastasis. In this study, we developed a multi-functional drug delivery system EINP@DOX consisting of a tea-derived polyphenol EGCG, iron ions and DOX. The system integrated the functions of tumor inhibition, diagnosis and metastasis prevention to achieve a systematic tumor treatment. The nanoscale size of EINP@DOX facilitated its accumulation in tumor tissues by means of the enhanced permeability and retention (EPR) effect, and it was then transferred to endosomes. The weakly acidic microenvironment in the endosomes of the tumor cells could destroy the coordination structure of EINP@DOX to realize the release of DOX for tumor therapy. Furthermore, the dissociative EGCG played the role of an adjuvant to restrain EMT and down-regulate the MMP levels, which could prevent the occurrence of tumor metastasis. Meanwhile, iron ions as superior magnetic resonance imaging (MRI) contrast agents provided visual evidence for the accurate location of EINP@DOX. In vitro and in vivo studies demonstrated that EINP@DOX showed a remarkable performance in tumor diagnosis and excellent therapeutic efficacy, inhibiting the metastasis of tumor cells effectively at the same time.

Graphical abstract: A multi-functional drug delivery system based on polyphenols for efficient tumor inhibition and metastasis prevention

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Publication details

The article was received on 15 Oct 2019, accepted on 11 Nov 2019 and first published on 13 Nov 2019


Article type: Paper
DOI: 10.1039/C9BM01646E
Biomater. Sci., 2020, Advance Article

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    A multi-functional drug delivery system based on polyphenols for efficient tumor inhibition and metastasis prevention

    S. Chen, J. Fan, D. Zheng, F. Liu, X. Zeng, G. Yan and X. Zhang, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/C9BM01646E

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