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Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy

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Abstract

For mRNA mediated cancer immunotherapy, Pam3 was incorporated as an adjuvant within lipid nanoparticles (LNPs) with OVA mRNA. The developed Pam3 incorporated LNPs showed successful expression of tumor antigens with enhanced immune stimulation. We demonstrated that the synergies of Pam3 LNPs could greatly improve the efficacy of tumor prevention by mRNA vaccines.

Graphical abstract: Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy

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Publication details

The article was received on 27 Sep 2019, accepted on 19 Nov 2019 and first published on 20 Nov 2019


Article type: Communication
DOI: 10.1039/C9BM01564G
Biomater. Sci., 2020, Advance Article

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    Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy

    K. Lee, S. Y. Kim, Y. Seo, M. H. Kim, J. Chang and H. Lee, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/C9BM01564G

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