Jump to main content
Jump to site search


Dual light-induced in situ antibacterial activities of biocompatibleTiO2/MoS2/PDA/RGD nanorod arrays on titanium

Author affiliations

Abstract

Prevention of bacterial infection and promotion of osseointegration are two important issues for titanium (Ti) implants in medical research. In addition, after a biofilm is formed on the surface of implants, the immune system and antibiotic therapy may fail. In this work, bio-functionalized titanium dioxide (TiO2)/molybdenum disulfide (MoS2)/polydopamine (PDA)/arginine-glycine-aspartic acid (RGD) nanorod arrays (NAs) are prepared on Ti implants to not only kill bacteria noninvasively upon co-irradiation of 660 nm visible light (VL) and 808 nm near infrared (NIR) light, but also promote the osteogenic activity simultaneously. Dual light irradiation triggers the TiO2/MoS2 NA to generate hyperthermia and reactive oxygen species (ROS) in 10 min. The synergistic effects of the generated hyperthermia and ROS increase the bacterial membrane permeability and bacteria are killed rapidly and efficiently in vitro and in vivo. The biofilm is also eradicated and RGD on the nanorods improves cell adhesion, proliferation, and osteogenic differentiation. The strategy described here for the design of bio-functionalized coatings on Ti implants has great clinical potential in orthopedics, dentistry, and other medical fields.

Graphical abstract: Dual light-induced in situ antibacterial activities of biocompatibleTiO2/MoS2/PDA/RGD nanorod arrays on titanium

Back to tab navigation

Supplementary files

Publication details

The article was received on 18 Sep 2019, accepted on 23 Oct 2019 and first published on 25 Oct 2019


Article type: Paper
DOI: 10.1039/C9BM01507H
Biomater. Sci., 2020, Advance Article

  •   Request permissions

    Dual light-induced in situ antibacterial activities of biocompatibleTiO2/MoS2/PDA/RGD nanorod arrays on titanium

    G. Zhang, X. Zhang, Y. Yang, R. Chi, J. Shi, R. Hang, X. Huang, X. Yao, P. K. Chu and X. Zhang, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/C9BM01507H

Search articles by author

Spotlight

Advertisements