Jump to main content
Jump to site search


Sustained protein therapeutics enabled by self-healing nanocomposite hydrogels for non-invasive bone regeneration

Author affiliations

Abstract

Bone tissue engineering based on stem cells, growth factors and bioactive scaffolds presents an appealing but challenging approach for rehabilitation of patients with bone defects. A versatile system with the capability for easy operation and precise protein delivery in specific locations is attractive for enhancing bone regeneration. Here, we develop a non-invasive delivery system based on injectable and self-healing nanocomposite hydrogels for sustained protein release, which has the potential to improve the current orthopedic strategy. Specifically, LAPONITE® (LAP) nanoplatelets are able to accelerate the gelation process through hydrogen bonds with polysaccharide matrices, endowing hydrogels with superior mechanical and rheological behaviors, along with better injectability and self-healing ability. Attractively, the strong static binding between LAP nanoplatelets and bone morphogenetic protein-2 (BMP-2) can form stable LAP@BMP-2 complexes. The results indicate that the complexes effectively preserve the intrinsic bioactivity of BMP-2 and prolong the release period for more than four weeks. Moreover, hydrogels incorporating with the LAP@BMP-2 complexes synergistically boost cell spreading, proliferation activity and osteogenesis, both in vitro and in vivo, compared with LAP or BMP-2 alone. Overall, this study proposes a valid platform for protein therapeutics and non-invasive bone repair.

Graphical abstract: Sustained protein therapeutics enabled by self-healing nanocomposite hydrogels for non-invasive bone regeneration

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Sep 2019, accepted on 01 Nov 2019 and first published on 04 Nov 2019


Article type: Paper
DOI: 10.1039/C9BM01455A
Biomater. Sci., 2020, Advance Article

  •   Request permissions

    Sustained protein therapeutics enabled by self-healing nanocomposite hydrogels for non-invasive bone regeneration

    Y. Zhang, M. Chen, Z. Dai, H. Cao, J. Li and W. Zhang, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/C9BM01455A

Search articles by author

Spotlight

Advertisements