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Porous ZnO modified silk sutures with dual light defined antibacterial, healing promotion and controlled self-degradation capabilities

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Abstract

Current sutures have disadvantages such as poor antibacterial activities, low healing effects, and a lack of self-degradation ability. To solve these problems, here a biocompatible and dual light (yellow and NIR light) responsive porous ZnO (PZ) was synthesized to modify silk thread to improve the healing rate, antibacterial activities and controlled self-degradation speed simultaneously. The prepared silk thread was characterized by using scanning electron microscopy (SEM) and X-ray diffractometry (XRD). Besides, the antibacterial activity, degradation, dual light responsive capability and cytocompatibility of the sample were evaluated. The obtained data strongly encourage the application of this silk thread for wound treatment. Furthermore, in vivo evaluation in mice revealed that the silk thread reduced surgical-site infection and enhanced wound healing. Therefore, this silk thread shows potential for application in wound treatment clinically.

Graphical abstract: Porous ZnO modified silk sutures with dual light defined antibacterial, healing promotion and controlled self-degradation capabilities

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Publication details

The article was received on 04 Sep 2019, accepted on 09 Oct 2019 and first published on 15 Oct 2019


Article type: Paper
DOI: 10.1039/C9BM01422E
Biomater. Sci., 2020, Advance Article

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    Porous ZnO modified silk sutures with dual light defined antibacterial, healing promotion and controlled self-degradation capabilities

    F. Cao, B. Zeng, Y. Zhu, F. Yu, M. Wang, X. Song, X. Cheng, L. Chen and X. Wang, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/C9BM01422E

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