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Biomimetic drug-delivery systems for the management of brain diseases

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Abstract

Acting as a double-edged sword, the blood–brain barrier (BBB) is essential for maintaining brain homeostasis by restricting the entry of small molecules and most macromolecules from blood. However, it also largely limits the brain delivery of most drugs. Even if a drug can penetrate the BBB, its accumulation in the intracerebral pathological regions is relatively low. Thus, an optimal drug-delivery system (DDS) for the management of brain diseases needs to display BBB permeability, lesion-targeting capability, and acceptable safety. Biomimetic DDSs, developed by directly utilizing or mimicking the biological structures and processes, provide promising approaches for overcoming the barriers to brain drug delivery. The present review summarizes the biological properties and biomedical applications of the biomimetic DDSs including the cell membrane-based DDS, lipoprotein-based DDS, exosome-based DDS, virus-based DDS, protein template-based DDS and peptide template-based DDS for the management of brain diseases.

Graphical abstract: Biomimetic drug-delivery systems for the management of brain diseases

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Publication details

The article was received on 31 Aug 2019, accepted on 28 Oct 2019 and first published on 29 Oct 2019


Article type: Review Article
DOI: 10.1039/C9BM01395D
Biomater. Sci., 2020, Advance Article

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    Biomimetic drug-delivery systems for the management of brain diseases

    Y. Chen, C. Wei, Y. Lyu, H. Chen, G. Jiang and X. Gao, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/C9BM01395D

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