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Issue 4, 2020

Recent progress in supramolecular peptide assemblies as virus mimics for cancer immunotherapy

Author affiliations

Abstract

Immunotherapy has revolutionized the field of cancer therapy. Nanomaterials can further improve the efficacy and safety of immunotherapy because of their tunability and multifunctionality. A supramolecular peptide assembly (SPA), as a close mimic of natural viruses, is a unique type of nanomaterial with high epitope valency, multifunctionality and biocompatibility. Given its great potential in cancer immunotherapy, especially in cancer vaccines, in the current review, we summarize the unique features of the SPA that are beneficial for cancer immunotherapy, and highlight the important progress in using SPAs as nanoscale carriers, antigens, adjuvants or multifunctional platforms. The current challenges faced by these SPAs are also briefly discussed.

Graphical abstract: Recent progress in supramolecular peptide assemblies as virus mimics for cancer immunotherapy

Article information


Submitted
29 Aug 2019
Accepted
08 Oct 2019
First published
08 Oct 2019

Biomater. Sci., 2020,8, 1045-1057
Article type
Review Article

Recent progress in supramolecular peptide assemblies as virus mimics for cancer immunotherapy

Y. Cai, W. Ran, Y. Zhai, J. Wang, C. Zheng, Y. Li and P. Zhang, Biomater. Sci., 2020, 8, 1045 DOI: 10.1039/C9BM01380F

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