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Multi-component supramolecular fibers with elastomeric properties and controlled drug release

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Abstract

Supramolecular materials based on hydrogen bonding ureido-pyrimidinones (UPy) are highly versatile substrates for tissue engineering, as they provide a platform in which specific functions can be introduced in a modular fashion by means of components with matching supramolecular motifs. In this work, a core–shell fiber mesh is generated by coaxial electrospinning of a robust elastomeric UPy-poly(hexamethylene carbonate) (UPy-PC) core with a hydrophilic shell of poly(ethylene glycol) (UPy-PEG), which is exploited to confer drug release properties to the load-bearing core. The effect of PEG chain length and supramolecular crosslink density on mechanical properties and drug elution profiles is investigated. Hydrated UPy-PC/UPy-PEG meshes containing 30 mol% of UPy-PEG have a Young's modulus matching that of UPy-PC meshes of approximately 0.5 MPa, and elongation at break of 600%. Drug release experiments with low molecular weight drugs encapsulated in the UPy-PEG shell during electrospinning reveal a combined role of drug and matrix hydrophilicity on the elution profile. Our results indicate that a hydrophobic drug is retained in the UPy-PEG shell for several days with a maximum drug release of 56 ± 8% after 14 days, a highly water soluble drug undergoes burst release within one day, and the UPy-modification of a highly water soluble compound increases its retention in the UPy-PEG shell up to multiple weeks. Taken together, our results indicate that the proposed multi-component system is a drug delivery vehicle of excellent versatility for applications requiring strong and durable materials.

Graphical abstract: Multi-component supramolecular fibers with elastomeric properties and controlled drug release

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Publication details

The article was received on 06 Aug 2019, accepted on 20 Oct 2019 and first published on 25 Oct 2019


Article type: Paper
DOI: 10.1039/C9BM01241A
Biomater. Sci., 2020, Advance Article
  • Open access: Creative Commons BY license
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    Multi-component supramolecular fibers with elastomeric properties and controlled drug release

    M. Putti, T. Mes, J. Huang, A. W. Bosman and P. Y. W. Dankers, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/C9BM01241A

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