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Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites

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Abstract

Cells respond to biophysical and biochemical signals. We developed a composite filament from collagen and silica particles modified to interact with collagen and/or present a laminin epitope (IKVAV) crucial for cell–matrix adhesion and signal transduction. This combines scaffolding and signaling and shows that local tuning of collagen organization enhances cell differentiation.

Graphical abstract: Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites

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Article information


Submitted
02 Jul 2019
Accepted
20 Dec 2019
First published
02 Jan 2020

Biomater. Sci., 2020, Advance Article
Article type
Communication

Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites

N. Debons, D. Dems, C. Hélary, S. Le Grill, L. Picaut, F. Renaud, N. Delsuc, M. Schanne-Klein, T. Coradin and C. Aimé, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/C9BM01029G

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