Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites

Nicolas Debons; Dounia Dems; Christophe Hélary; Sylvain Le Grill; Lise Picaut; Flore Renaud; Nicolas Delsuc; Marie-Claire Schanne-Klein; Thibaud Coradin; Carole Aimé

doi:10.1039/C9BM01029G

Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites†

Nicolas Debons,‡^a Dounia Dems,‡^a Christophe Hélary,^a Sylvain Le Grill,^a Lise Picaut,^ab Flore Renaud,^c Nicolas Delsuc,

^d Marie-Claire Schanne-Klein,

^e Thibaud Coradin

^a and Carole Aimé

§*^a

Author affiliations

* Corresponding authors

^a Sorbonne Université, CNRS, Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Paris, France
E-mail: Carole.aime@ens.fr

^b Sorbonne Université, CNRS, Institut des Nanosciences de Paris (INSP), Paris, France

^c INSERM, UMR 1186, EPHE-PSL, Gustave Roussy, 94805 Villejuif, France

^d Laboratoire des Biomolécules, LBM, Département de Chimie, Ecole normale supérieure, PSL Research University, Sorbonne Université, CNRS, 24 rue Lhomond, 75005 Paris, France

^e Laboratoire d'Optique et Biosciences, Ecole Polytechnique, CNRS, Inserm, Institut Polytechnique de Paris, F-91128 Palaiseau, France

Abstract

Cells respond to biophysical and biochemical signals. We developed a composite filament from collagen and silica particles modified to interact with collagen and/or present a laminin epitope (IKVAV) crucial for cell–matrix adhesion and signal transduction. This combines scaffolding and signaling and shows that local tuning of collagen organization enhances cell differentiation.

Biomaterials Science

Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites†

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Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites

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