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Analysis of Benzodiazepines by Thermal Desorption Direct Analysis in Real Time Mass Spectrometry (TD-DART-MS)

Abstract

One of the several classes of novel psychoactive substances (NPS) that present analytical challenges for forensic chemists are benzodiazepines. Like other NPS classes, the emergence of new compounds within this class continues, creating a need for the development of new techniques and methods that allow for rapid detection and identification of these compounds in forensics laboratories. This work investigates the use of thermal desorption direct analysis in real time mass spectrometry (TD-DART-MS) as a tool for the rapid and sensitive detection of benzodiazepines. A suite of 19 benzodiazepines were investigated to determine their representative responses. Limits of detection (LODs) for these compounds were found to range from 0.1 ng to 8 ng. Competitive ionization studies highlighted that detection of these compounds in the presence of cutting agents and low amounts of heroin was possible. Additionally, the presence of three complex background matrices that are common in trace detection applications (artificial fingerprint residue, dirt, and plasticizers) were investigated and were shown to have a minimal effect on the detection of these compounds. TD-DART-MS was demonstrated as a potentially powerful tool for rapid on-site or laboratory-based screening.

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Supplementary files

Article information


Submitted
31 Aug 2020
Accepted
12 Oct 2020
First published
13 Oct 2020

Anal. Methods, 2020, Accepted Manuscript
Article type
Paper

Analysis of Benzodiazepines by Thermal Desorption Direct Analysis in Real Time Mass Spectrometry (TD-DART-MS)

S. Jones, E. Sisco and I. Marginean, Anal. Methods, 2020, Accepted Manuscript , DOI: 10.1039/D0AY01650K

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