Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 21st October 2020 from 07:00 AM to 07:00 PM (BST).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.



A spot test for determination of residual TBA levels in 18F-radiotracers for human use using Dragendorff reagent

Author affiliations

Abstract

When utilizing [18F]tetrabutylammonium fluoride ([18F]TBAF) in the synthesis of 18F-labeled radiotracers for clinical positron emission tomography (PET) imaging, it is necessary to confirm that residual TBA levels in formulated doses do not exceed established specifications (≤2.6 mg per patient dose). Historically this has been accomplished using HPLC, but this is time consuming for short-lived PET radiotracers and limited by the need for expensive equipment. This motivated us to introduce a TLC spot test for determining residual TBA, and we have developed a new method which employs the Dragendorff reagent. Herein we report details of the TLC method and use it to quantify residual TBA in different formulations of 6-[18F]fluoro-DOPA.

Graphical abstract: A spot test for determination of residual TBA levels in 18F-radiotracers for human use using Dragendorff reagent

Back to tab navigation

Article information


Submitted
17 Aug 2020
Accepted
23 Sep 2020
First published
24 Sep 2020

Anal. Methods, 2020, Advance Article
Article type
Technical Note

A spot test for determination of residual TBA levels in 18F-radiotracers for human use using Dragendorff reagent

S. S. Tanzey, A. V. Mossine, A. R. Sowa, J. Torres, A. F. Brooks, M. S. Sanford and P. J. H. Scott, Anal. Methods, 2020, Advance Article , DOI: 10.1039/D0AY01565B

Social activity

Search articles by author

Spotlight

Advertisements