A hemicyanine-based “turn-on” fluorescent probe for the selective detection of Cu2+ ions and imaging in living cells

Bai Li; Jiejian Kou; Huihui Mei; Xin Gu; Minghui Wang; Xinmei Xie; Kuoxi Xu

doi:10.1039/D0AY01461C

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A hemicyanine-based “turn-on” fluorescent probe for the selective detection of Cu²⁺ ions and imaging in living cells†

Bai Li,^a Jiejian Kou,^b Huihui Mei,^a Xin Gu,^a Minghui Wang,^a Xinmei Xie*^b and Kuoxi Xu

*^a

Author affiliations

* Corresponding authors

^a Henan Engineering Research Center of Industrial Recirculating Water Treatment, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan, P. R. China
E-mail: xukx@henu.edu.cn

^b Institute of Pharmacy, Henan University, Kaifeng, Henan, P. R. China
E-mail: xxm@vip.henu.edu.cn

Abstract

A novel hemicyanine-based fluorescent probe was developed for the fast, selective, and reversible detection of Cu²⁺ ions with “turn-on” fluorescence response in the aqueous solution. The sensing mode was demonstrated through fluorescence, UV-vis, HRMS, ¹H NMR, and DFT calculations. The probe was successfully used for the imaging of Cu²⁺ ions in living cells.

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Article information

DOI: https://doi.org/10.1039/D0AY01461C
Article type: Communication
Submitted: 31 Jul 2020
Accepted: 11 Aug 2020
First published: 12 Aug 2020

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Anal. Methods, 2020,12, 4181-4184

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A hemicyanine-based “turn-on” fluorescent probe for the selective detection of Cu²⁺ ions and imaging in living cells

B. Li, J. Kou, H. Mei, X. Gu, M. Wang, X. Xie and K. Xu, Anal. Methods, 2020, 12, 4181 DOI: 10.1039/D0AY01461C

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Analytical Methods