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A lateral flow biosensor based on gold nanoparticles detects four hemorrhagic fever viruses

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Abstract

The pathogen of viral hemorrhagic fever (VHF), which is harmful to human health, is a hemorrhagic fever virus. Clinicians have long needed convenient and sensitive point-of-care rapid diagnostic tests (RDTs) for hemorrhagic fever viruses. Commonly used methods for pathogen detection rely on conventional culture-based tests, antibody-based assays and polymerase chain reaction (PCR)-based techniques. However, these methods are costly, laborious and time-consuming. Herein, we present a simple and sensitive biosensor for the rapid detection of hemorrhagic fever viruses. For this assay, we develop lateral flow biosensors (LFBs) based on magnetic beads and nicking enzyme-assisted isothermal strand-displacement amplification (SDA) for the detection of hemorrhagic fever viruses. The detection limit of this assay is 10 fM.

Graphical abstract: A lateral flow biosensor based on gold nanoparticles detects four hemorrhagic fever viruses

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Article information


Submitted
07 Jun 2020
Accepted
05 Oct 2020
First published
07 Oct 2020

Anal. Methods, 2020, Advance Article
Article type
Paper

A lateral flow biosensor based on gold nanoparticles detects four hemorrhagic fever viruses

J. Zhao, S. Fang, Y. Liu, L. Zeng and Z. He, Anal. Methods, 2020, Advance Article , DOI: 10.1039/D0AY01137A

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