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Mitochondrial-targeted deep-red fluorescent probe for ATP and its application in living cells and zebrafish

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Abstract

A novel mitochondrial-targeted deep-red fluorescence ATP probe, NIR-A, is reported. The probe showed a fast, selective, and reversible response for ATP with a significant turn-on fluorescence signal at 663 nm with a large Stokes shift of 81 nm. Additionally, the introduction of TPP enabled TPP-endowed NIR-A to be enriched predominantly in the mitochondria. NIR-A was successfully applied to monitor ATP fluctuation in Ramos cells and zebrafish in real-time with good biocompatibility.

Graphical abstract: Mitochondrial-targeted deep-red fluorescent probe for ATP and its application in living cells and zebrafish

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Article information


Submitted
10 May 2020
Accepted
11 Jun 2020
First published
15 Jun 2020

Anal. Methods, 2020, Advance Article
Article type
Communication

Mitochondrial-targeted deep-red fluorescent probe for ATP and its application in living cells and zebrafish

W. Peng, M. Hu and J. Zhang, Anal. Methods, 2020, Advance Article , DOI: 10.1039/D0AY00942C

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