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Chiral separations with crosslinked cellulose derivatives attached onto hybrid silica monolith particles via the thiol–ene click reaction

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Abstract

A hybrid silica monolith containing vinyl groups was synthesized by a sol–gel method, and then ground and treated, yielding silica particles with a 3–5 μm particle size and a 10–20 nm pore size. Cellulose derivatives containing 3,5-dimethylphenylcarbamate groups and methacrylate groups regioselectively were then immobilized onto the surface of the above particles by the thiol–ene click reaction using an alkanedithiol as the crosslinking agent, thus forming a solvent-resisting crosslinked network structure attached onto the surface of the particles. The immobilization degree was more than 80%, and the back pressure of the chiral stationary phase (CSP) packed column was relatively low and was maintained at around 3.0 MPa. The as-prepared CSPs were shown to be able to effectively separate various enantiomers with different mobile phases.

Graphical abstract: Chiral separations with crosslinked cellulose derivatives attached onto hybrid silica monolith particles via the thiol–ene click reaction

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Article information


Submitted
15 Apr 2020
Accepted
25 Apr 2020
First published
28 Apr 2020

Anal. Methods, 2020, Advance Article
Article type
Paper

Chiral separations with crosslinked cellulose derivatives attached onto hybrid silica monolith particles via the thiol–ene click reaction

Y. Zhou, Q. Liang, Z. Zhang, Z. Wang and M. Huang, Anal. Methods, 2020, Advance Article , DOI: 10.1039/D0AY00772B

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